| Origin-Destination | stops | Departure | Arrival | Date | Price |
| New York - Guatemala City | direct | 09:10 | 14:10 | | Find |
| Los Angeles - Guatemala City | direct | 10:55 | 15:30 | 24.09.2025 | from $107 |
| Miami - Guatemala City | direct | 18:45 | 21:00 | 14.08.2025 | from $76 |
| Chicago - Guatemala City | direct | 09:30 | 14:00 | 21.06.2025 | from $90 |
| San Francisco - Guatemala City | 1 | 05:00 | 12:40 | | Find |
| Boston - Guatemala City | 1 | 10:30 | 18:25 | | Find |
| Washington - Guatemala City | direct | 05:10 | 09:35 | | Find |
| Seattle - Guatemala City | 1 | 03:37 | 12:40 | 21.06.2025 | from $131 |
| Atlanta - Guatemala City | direct | 04:11 | 07:31 | 17.10.2025 | from $139 |
| Orlando - Guatemala City | direct | 14:00 | 16:52 | 21.06.2025 | from $100 |
| Minneapolis - Guatemala City | direct | 14:00 | 22:50 | 21.06.2025 | from $202 |
| Las Vegas - Guatemala City | 1 | 23:27 | 06:46 | | Find |
| Charlotte - Guatemala City | 1 | 20:09 | 02:46 | 21.06.2025 | from $83 |
| Denver - Guatemala City | 1 | 12:30 | 20:02 | 21.06.2025 | from $82 |
| Philadelphia - Guatemala City | 1 | 18:50 | 02:14 | 21.06.2025 | from $69 |
| Detroit - Guatemala City | 1 | 13:40 | 21:35 | 21.06.2025 | from $124 |
| Tampa - Guatemala City | 1 | 20:32 | 02:03 | 21.06.2025 | from $96 |
| Houston - Guatemala City | direct | 19:27 | 22:05 | | Find |
| Columbus - Guatemala City | 1 | 12:00 | 19:05 | | Find |
| San Diego - Guatemala City | 1 | 03:50 | 11:30 | | Find |
| Honolulu - Guatemala City | 1 | 06:30 | 18:35 | 21.06.2025 | from $187 |
| Sacramento - Guatemala City | 1 | 05:00 | 12:40 | 21.06.2025 | from $174 |
| Dallas - Guatemala City | direct | 00:37 | 03:50 | | Find |
| Cleveland - Guatemala City | 1 | 18:47 | 02:14 | 21.06.2025 | from $111 |
| Jacksonville - Guatemala City | 1 | 20:31 | 02:14 | 21.06.2025 | from $190 |
| Pittsburgh - Guatemala City | 1 | 12:00 | 19:05 | 21.06.2025 | from $111 |
| Raleigh/Durham - Guatemala City | 1 | 11:50 | 18:36 | 21.06.2025 | from $83 |
| Saint Louis - Guatemala City | 1 | 11:25 | 18:36 | 21.06.2025 | from $116 |
| Austin - Guatemala City | 1 | 15:50 | 21:35 | 21.06.2025 | from $128 |
| Charleston - Guatemala City | 1 | 12:00 | 18:34 | 21.06.2025 | from $83 |
| Portland - Guatemala City | 1 | 02:50 | 11:30 | 21.06.2025 | from $111 |
| Salt Lake City - Guatemala City | 1 | 18:59 | 02:21 | 21.06.2025 | from $132 |
| Phoenix - Guatemala City | 1 | 23:41 | 06:46 | 21.06.2025 | from $113 |
| Buffalo - Guatemala City | 1 | 10:40 | 18:34 | 21.06.2025 | from $139 |
| New Orleans - Guatemala City | 1 | 12:10 | 18:25 | 21.06.2025 | from $127 |
| Norfolk - Guatemala City | 1 | 18:50 | 02:14 | 21.06.2025 | from $170 |
| Cincinnati - Guatemala City | 1 | 12:20 | 19:15 | 21.06.2025 | from $223 |
| Nashville - Guatemala City | 1 | 12:20 | 19:05 | 21.06.2025 | from $128 |
| Anchorage - Guatemala City | 2 | 00:50 | 16:21 | 21.06.2025 | from $191 |
| Boise - Guatemala City | 1 | 13:20 | 21:35 | 21.06.2025 | from $131 |
| San Antonio - Guatemala City | 1 | 01:00 | 06:46 | 21.06.2025 | from $132 |
| Savannah - Guatemala City | 1 | 20:03 | 02:46 | 21.06.2025 | from $152 |
| Richmond - Guatemala City | 1 | 11:45 | 19:15 | 21.06.2025 | from $91 |
| Des Moines - Guatemala City | 1 | 11:30 | 19:15 | 21.06.2025 | from $240 |
| Kansas City - Guatemala City | 1 | 14:48 | 21:35 | 21.06.2025 | from $145 |
| Indianapolis - Guatemala City | 1 | 20:00 | 02:46 | 21.06.2025 | from $111 |
| Myrtle Beach - Guatemala City | 1 | 11:00 | 19:15 | 21.06.2025 | from $113 |
| Greenville - Guatemala City | 1 | 12:45 | 19:15 | 21.06.2025 | from $269 |
| Huntsville - Guatemala City | 1 | 20:23 | 02:46 | 21.06.2025 | from $236 |
| Spokane - Guatemala City | 1 | 00:35 | 11:30 | 21.06.2025 | from $121 |
| Fort Myers - Guatemala City | 1 | 12:00 | 19:15 | 21.06.2025 | from $193 |
| Albuquerque - Guatemala City | 1 | 13:30 | 20:29 | 21.06.2025 | from $206 |
| Columbia - Guatemala City | 1 | 12:13 | 18:27 | | Find |
| Grand Rapids - Guatemala City | 1 | 11:00 | 19:05 | 21.06.2025 | from $263 |
| Santa Ana - Guatemala City | 1 | 20:11 | 04:35 | | Find |
| Tallahassee - Guatemala City | 1 | 12:00 | 19:15 | 21.06.2025 | from $268 |
| Lincoln - Guatemala City | 2 | 12:00 | 00:50 | 21.06.2025 | from $409 |
| Reno - Guatemala City | 1 | 03:59 | 12:40 | 21.06.2025 | from $100 |
| Memphis - Guatemala City | 1 | 12:55 | 20:04 | 21.06.2025 | from $156 |
| Wilmington - Guatemala City | 1 | 12:25 | 19:15 | 21.06.2025 | from $312 |
| Dayton - Guatemala City | 1 | 19:37 | 02:46 | 21.06.2025 | from $250 |
| Providence - Guatemala City | 1 | 11:00 | 19:15 | 21.06.2025 | from $252 |
| Oklahoma City - Guatemala City | 1 | 15:39 | 21:35 | 21.06.2025 | from $152 |
| Hartford - Guatemala City | 1 | 11:00 | 19:15 | 21.06.2025 | from $101 |
| Louisville - Guatemala City | 1 | 12:00 | 19:15 | | Find |
| Lexington - Guatemala City | 1 | 12:00 | 19:15 | 21.06.2025 | from $295 |
| El Paso - Guatemala City | 1 | 14:00 | 21:35 | 21.06.2025 | from $346 |
| Knoxville - Guatemala City | 1 | 12:00 | 19:15 | 21.06.2025 | from $252 |
| Sioux Falls - Guatemala City | 1 | 13:00 | 20:29 | 21.06.2025 | from $322 |
| Milwaukee - Guatemala City | 1 | 11:41 | 19:15 | 21.06.2025 | from $162 |
| McAllen - Guatemala City | 1 | 15:34 | 21:35 | 21.06.2025 | from $315 |
| Fresno - Guatemala City | 2 | 08:35 | 18:45 | 21.06.2025 | from $215 |
| Fort Walton Beach - Guatemala City | 1 | 19:16 | 02:46 | 21.06.2025 | from $279 |
| Cedar Rapids - Guatemala City | 1 | 11:40 | 19:15 | 21.06.2025 | from $523 |
| Jackson - Guatemala City | 1 | 15:25 | 21:35 | 21.06.2025 | from $334 |
| Eugene - Guatemala City | 1 | 03:14 | 11:30 | 21.06.2025 | from $152 |
| Allentown - Guatemala City | 1 | 11:00 | 19:15 | | Find |
| Middletown - Guatemala City | 1 | 11:00 | 19:15 | 21.06.2025 | from $226 |
| Shreveport - Guatemala City | 1 | 22:02 | 04:35 | | Find |
| Idaho Falls - Guatemala City | 2 | 00:30 | 11:30 | 21.06.2025 | from $181 |
| Tulsa - Guatemala City | 1 | 14:59 | 21:35 | 21.06.2025 | from $173 |
| Burbank - Guatemala City | 2 | 01:55 | 12:35 | | Find |
| Peoria - Guatemala City | 1 | 11:50 | 19:15 | | Find |
| Greensboro/High Point - Guatemala City | 1 | 11:30 | 18:27 | 21.06.2025 | from $226 |
| Bloomington - Guatemala City | 1 | 12:25 | 20:52 | | Find |
| Amarillo - Guatemala City | 1 | 14:07 | 20:29 | 21.06.2025 | from $349 |
| Moline - Guatemala City | 1 | 11:45 | 19:15 | | Find |
| Brownsville - Guatemala City | 1 | 13:30 | 20:02 | | Find |
| Chattanooga - Guatemala City | 1 | 19:59 | 02:46 | 21.06.2025 | from $339 |
| Grand Island - Guatemala City | 1 | 12:40 | 20:29 | | Find |
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