| Origin-Destination | stops | Departure | Arrival | Date | Price |
| Guatemala City - New York | direct | 08:50 | 13:00 | 27.11.2025 | from $145 |
| Guatemala City - Los Angeles | direct | 16:50 | 21:56 | 07.11.2025 | from $44 |
| Guatemala City - Miami | direct | 06:45 | 09:25 | 18.11.2025 | from $100 |
| Guatemala City - Chicago | direct | 00:47 | 04:55 | | Find |
| Guatemala City - San Francisco | 1 | 23:37 | 08:15 | | Find |
| Guatemala City - Boston | 1 | 21:04 | 04:31 | 09.11.2025 | from $136 |
| Guatemala City - Washington | direct | 09:52 | 14:00 | 04.11.2025 | from $116 |
| Guatemala City - Seattle | 1 | 19:30 | 05:00 | | Find |
| Guatemala City - Atlanta | direct | 17:00 | 20:18 | 03.12.2025 | from $143 |
| Guatemala City - Orlando | direct | 18:05 | 21:00 | 09.11.2025 | from $136 |
| Guatemala City - Las Vegas | 1 | 21:05 | 05:08 | | Find |
| Guatemala City - Charlotte | 1 | 13:14 | 20:03 | | Find |
| Guatemala City - Denver | direct | 10:10 | 17:43 | | Find |
| Guatemala City - Philadelphia | 1 | 20:25 | 03:45 | | Find |
| Guatemala City - Detroit | 1 | 14:05 | 21:15 | | Find |
| Guatemala City - Tampa | 1 | 21:04 | 03:48 | | Find |
| Guatemala City - Houston | direct | 22:55 | 01:47 | | Find |
| Guatemala City - Columbus | 1 | 20:15 | 03:34 | | Find |
| Guatemala City - San Diego | 1 | 13:55 | 21:43 | | Find |
| Guatemala City - Honolulu | 1 | 13:55 | 02:53 | 07.12.2025 | from $299 |
| Guatemala City - Sacramento | 1 | 14:45 | 23:25 | | Find |
| Guatemala City - Dallas | direct | 21:25 | 00:50 | 05.11.2025 | from $152 |
| Guatemala City - Cleveland | 1 | 21:05 | 04:26 | | Find |
| Guatemala City - Jacksonville | 1 | 21:05 | 04:11 | | Find |
| Guatemala City - Pittsburgh | 1 | 19:30 | 02:51 | | Find |
| Guatemala City - Raleigh/Durham | 1 | 21:04 | 03:39 | | Find |
| Guatemala City - Saint Louis | 1 | 20:15 | 03:13 | | Find |
| Guatemala City - Austin | 1 | 19:30 | 01:04 | | Find |
| Guatemala City - Charleston | 1 | 20:25 | 03:35 | | Find |
| Guatemala City - Portland | 1 | 19:30 | 05:09 | 09.11.2025 | from $100 |
| Guatemala City - Salt Lake City | 1 | 19:30 | 03:34 | | Find |
| Guatemala City - Phoenix | 1 | 19:30 | 03:12 | | Find |
| Guatemala City - Buffalo | 1 | 20:25 | 04:59 | | Find |
| Guatemala City - New Orleans | 1 | 21:05 | 03:03 | | Find |
| Guatemala City - Norfolk | 1 | 19:05 | 01:55 | | Find |
| Guatemala City - Cincinnati | 1 | 20:25 | 02:53 | | Find |
| Guatemala City - Nashville | 1 | 21:05 | 03:50 | | Find |
| Guatemala City - Anchorage | 1 | 00:21 | 13:10 | | Find |
| Guatemala City - Boise | 1 | 01:19 | 19:08 | | Find |
| Guatemala City - San Antonio | 1 | 19:30 | 01:18 | | Find |
| Guatemala City - Savannah | 1 | 20:25 | 03:04 | | Find |
| Guatemala City - Des Moines | 1 | 21:32 | 04:40 | | Find |
| Guatemala City - Kansas City | 1 | 21:32 | 04:00 | | Find |
| Guatemala City - Indianapolis | 1 | 20:25 | 03:31 | | Find |
| Guatemala City - Myrtle Beach | 1 | 20:25 | 03:30 | | Find |
| Guatemala City - Greenville | 1 | 20:25 | 02:35 | | Find |
| Guatemala City - Huntsville | 1 | 21:05 | 04:04 | | Find |
| Guatemala City - Spokane | 2 | 19:30 | 07:15 | | Find |
| Guatemala City - Fort Myers | 1 | 20:25 | 03:33 | | Find |
| Guatemala City - Albuquerque | 1 | 19:30 | 02:55 | | Find |
| Guatemala City - Columbia | 1 | 20:25 | 03:41 | | Find |
| Guatemala City - Grand Rapids | 1 | 13:00 | 20:52 | | Find |
| Guatemala City - Santa Ana | 1 | 21:05 | 05:33 | | Find |
| Guatemala City - Tallahassee | 1 | 20:55 | 04:33 | | Find |
| Guatemala City - Lincoln | 2 | 11:40 | 23:34 | | Find |
| Guatemala City - Reno | 1 | 14:45 | 00:25 | | Find |
| Guatemala City - Omaha | 1 | 21:05 | 04:17 | | Find |
| Guatemala City - Memphis | 1 | 21:05 | 03:37 | | Find |
| Guatemala City - Little Rock | 1 | 13:00 | 19:29 | | Find |
| Guatemala City - Wilmington | 1 | 20:25 | 04:55 | | Find |
| Guatemala City - Dayton | 1 | 19:30 | 03:10 | | Find |
| Guatemala City - Providence | 1 | 20:25 | 04:45 | 09.11.2025 | from $95 |
| Guatemala City - Hartford | 1 | 19:30 | 03:52 | | Find |
| Guatemala City - Oklahoma City | 1 | 21:05 | 03:09 | | Find |
| Guatemala City - Louisville | 1 | 20:25 | 03:35 | | Find |
| Guatemala City - Lexington | 1 | 20:25 | 03:20 | | Find |
| Guatemala City - El Paso | 1 | 19:30 | 01:25 | | Find |
| Guatemala City - Knoxville | 1 | 20:25 | 03:06 | | Find |
| Guatemala City - McAllen | 1 | 21:05 | 03:15 | | Find |
| Guatemala City - Milwaukee | 1 | 19:30 | 03:04 | | Find |
| Guatemala City - Sioux Falls | 2 | 11:40 | 23:41 | | Find |
| Guatemala City - Fresno | 1 | 01:19 | 18:11 | | Find |
| Guatemala City - Fort Walton Beach | 1 | 19:30 | 01:00 | | Find |
| Guatemala City - Cedar Rapids | 1 | 21:32 | 05:57 | | Find |
| Guatemala City - Jackson | 1 | 21:05 | 03:00 | | Find |
| Guatemala City - Eugene | 2 | 13:55 | 02:00 | | Find |
| Guatemala City - Allentown | 1 | 20:25 | 04:30 | | Find |
| Guatemala City - Middletown | 1 | 20:25 | 04:35 | | Find |
| Guatemala City - Shreveport | 1 | 22:35 | 04:35 | | Find |
| Guatemala City - Idaho Falls | 2 | 17:25 | 04:45 | | Find |
| Guatemala City - Tulsa | 1 | 21:05 | 03:36 | | Find |
| Guatemala City - Burbank | 1 | 13:00 | 00:10 | | Find |
| Guatemala City - Peoria | 1 | 20:25 | 04:30 | | Find |
| Guatemala City - Bloomington | 1 | 20:25 | 04:10 | | Find |
| Guatemala City - Greensboro/High Point | 1 | 20:25 | 03:30 | | Find |
| Guatemala City - Amarillo | 1 | 19:30 | 02:39 | | Find |
| Guatemala City - Moline | 1 | 20:25 | 04:41 | | Find |
| Guatemala City - Brownsville | 1 | 19:30 | 01:37 | | Find |
| Guatemala City - Chattanooga | 1 | 20:25 | 02:45 | | Find |
| Guatemala City - Grand Island | 1 | 21:32 | 04:57 | | Find |
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